Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities

Oxidized, damaged and misfolded proteins accumulate during aging contribute to impaired cell function tissue homeodynamics. Damaged are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates low proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on or type it is unknown how functions in exceptionally old mice. The aim of this study was investigate two activities (caspase-like chymotrypsin-like) several tissues (lung, heart, axillary lymph nodes, liver, kidney) cells (peritoneal leukocytes) from adult (28 ± 4 weeks, n = 12), (76 9) (128 BALB/c female different age-related changes activity considered, so there no universal decline with age Interestingly, mice displayed better maintained activities, suggesting that preserved associated successful aging.